Does the time difference between Manila and Mexico City change during the year?

No. The gap stays at 14h all year.

When is the best time to call Mexico City from Manila?

There is no overlap between standard working days, so one side has to call early or late.

Manila is 14h ahead of Mexico City. This gap is the same all year — neither city shifts its clocks relative to the other.

Manila

Philippines

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Mexico City

Mexico

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A 9-to-5 working day in Manila does not overlap one in Mexico City at all — somebody has to take the call outside office hours.

City	Time zone	UTC offset
Manila · Philippines	Asia/Manila	UTC+8
Mexico City · Mexico	America/Mexico_City	UTC−6

What is the time difference between Manila and Mexico City?: Manila is 14h ahead of Mexico City. This gap is the same all year — neither city shifts its clocks relative to the other.
Does the time difference between Manila and Mexico City change during the year?: No. The gap stays at 14h all year.
When is the best time to call Mexico City from Manila?: There is no overlap between standard working days, so one side has to call early or late.