Does the time difference between Manila and Rome change during the year?

Yes. Because of daylight saving time the gap moves between +6h and +7h.

When is the best time to call Rome from Manila?

Between 15:00 and 17:00 in Manila, which is 09:00 to 11:00 in Rome.

Manila is 6h ahead of Rome. This gap is not fixed: daylight saving time moves it between +6h and +7h during the year.

Manila

Philippines

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Rome

Italy

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A 9-to-5 day in each city overlaps for 2h. That is 15:00–17:00 in Manila, which is 09:00–11:00 in Rome.

City	Time zone	UTC offset
Manila · Philippines	Asia/Manila	UTC+8
Rome · Italy	Europe/Rome	UTC+2

What is the time difference between Manila and Rome?: Manila is 6h ahead of Rome. This gap is not fixed: daylight saving time moves it between +6h and +7h during the year.
Does the time difference between Manila and Rome change during the year?: Yes. Because of daylight saving time the gap moves between +6h and +7h.
When is the best time to call Rome from Manila?: Between 15:00 and 17:00 in Manila, which is 09:00 to 11:00 in Rome.